منابع مشابه
OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.
An immune response is essential for protection against infection, but, in many individuals, aberrant responses against self tissues cause autoimmune diseases such as rheumatoid arthritis (RA). How to diminish the autoimmune response while not augmenting infectious risk is a challenge. Modern targeted therapies such as anti-TNF or anti-CD20 antibodies ameliorate disease, but at the cost of some ...
متن کاملCancer Therapy: Preclinical Combining EGFR and mTOR Blockade for the Treatment of Epithelioid Sarcoma
Purpose: Molecular deregulations underlying epithelioid sarcoma (ES) progression are poorly understood yet critically needed to develop new therapies. Epidermal growth factor receptor (EGFR) is overexpressed in ES; using preclinical models, we examined the ES EGFR role and assessed anti-ES EGFR blockade effects, alone and with mTOR inhibition. Experimental Design: EGFR and mTOR expression/activ...
متن کاملCombining EGFR and mTOR blockade for the treatment of epithelioid sarcoma.
PURPOSE Molecular deregulations underlying epithelioid sarcoma (ES) progression are poorly understood yet critically needed to develop new therapies. Epidermal growth factor receptor (EGFR) is overexpressed in ES; using preclinical models, we examined the ES EGFR role and assessed anti-ES EGFR blockade effects, alone and with mTOR inhibition. EXPERIMENTAL DESIGN EGFR and mTOR expression/activ...
متن کاملInterruption of OX40L signaling prevents costimulation blockade-resistant allograft rejection.
The potential of costimulation blockade to serve as a novel transplant immunosuppression strategy has been explored for over 20 years, culminating in the recent clinical approval of belatacept for renal transplant patients. Despite improving long-term graft function and survival compared with calcineurin inhibitors, clinical acceptance of belatacept has been hindered by elevated rates of acute ...
متن کاملOX40L blockade and allergen-induced airway responses in subjects with mild asthma
BACKGROUND The OX40/OX40L interaction contributes to an optimal T cell response following allergic stimuli and plays an important role in the maintenance and reactivation of memory T effector cells. OBJECTIVE We tested whether treatment with an anti-OX40L monoclonal antibody (MAb) would inhibit allergen-induced responses in subjects with asthma. METHODS Twenty-eight mild, atopic asthmatic s...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2017
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd.2017.207